Home owners could face mortgage rises of up to £14,000 a year as they exit low fixed rate markets, adding to the erosion of living standards, Labor said.
Analysis by the party shows predicted annual increases in the cost of buying an average home on a mortgage of 80% in all UK constituencies.
London seats top the ranking, with the highest increases expected in Kensington, where costs are expected to rise by £13,980.
The cities of London and Westminster, and then Chelsea and Fulham come next, with potential increases of £11,730 and £11,480 respectively.
Mortgages in Richmond Park, Hampstead and Kilburn could increase by £9,040 by £8,740 and Westminster North by £8,450, according to the analysis.
Further down the list, Sheffield Hallam is expected to increase mortgages by £3,080, North East Derbyshire by £2,070, and Plymouth, Sutton and Devonport by £1,850.
Householders in the Rhondda and Easington have seen the lowest increases, £1,030 and £910 respectively.
Shadow chancellor Rachel Reeves said: “The Tory mortgage penalty is devastating to family finances and is holding back our economy.
“The country is reeling from 13 years of Conservative mismanagement, and families are being asked to pay more on their mortgage again.
“People are asking themselves if they or their family are better off under the Tories. The answer is no.
“By stabilizing the economy, making it stronger and growing, Labor will stop us lurching from crisis to crisis, and make Britain prosperous again.”
Ms Reeves is due to visit estate agents in Finchley and Golders Green on Thursday – where the cost of a typical mortgage will rise by £7,490 a year – to discuss the impact of rising mortgages on business, homeowners and on buyers.
The Office for National Statistics has predicted that more than 1.4 million households will be at risk of interest rate rises when they renew their fixed-rate mortgages this year.
A series of Bank of England base rate hikes have taken place over the past year, but borrowers on fixed rate mortgages have been far behind their immediate impact. Some people may be in for a shock when they come to renew.
A senior Tory source said: “Under Labour, the number of first-time buyers has fallen to an all-time low, the number of homes built is an all-time low, and home ownership has been put out of reach for millions.
“The Labor Party… brings no real change to the issues that matter to the British people. We have a real plan to halve inflation this year and build a better Britain.”